SINALIZAÇÃO REDOX

A INVESTIGAÇÃO DOS SINALIZADORES DE REDOX

Diversa e profunda investigação, realizada por cientistas independentes de todo o mundo, confirmaram o papel essencial de que se revestem os sinalizadores de redox para a saúde celular. A realização de investigação e a publicação de artigos acerca dos sinalizadores de redox estão a surgir, cada vez, em maior número, tornando-o num dos campos de investigação científica de mais rápido crescimento.

ASEA é a primeira e única solução bebível contendo moléculas sinalizadoras de redox existentes fora das células vivas, que podem ser, deste modo, utilizadas para manter o equilíbrio de que o organismo necessita para suportar um funcionamento adequado do sistema imunológico e apoiar o processo de cura celular.

Redox Signaling Research Links:

• Critical Care 10(208) (2006), "Reactive oxygen species: toxic molecules or spark of life?", Shelden Magder(http://ccforum.com/content/10/1/208).

• Biochemical Pharmacology 70 (2005) 811-823, "Redox regulation: A new challenge for pharmacology", Daniel Frein, Stefan Schildknecht (http://www.ncbi.nlm.nih.gov/pubmed/15899473).

• J Radiat Res (Tokyo 2004) 45(3) 357-72 "Oxidative stress, radiation-adaptive responses, and aging", Miura Y. (http://www.ncbi.nlm.nih.gov/pubmed/15613781).

• J Cell Bio: minireview, "Specificity in reactive oxidant signaling: think globally, act locally", Lance S. Terada (http://www.ncbi.nlm.nih.gov/pubmed/16923830).

• Respir Res (2002) 3(26), "Oxygen-sensing mechanisms and regulation of redox-responsive transcription factors in development and pathophysiology", Haddad JJ.(http://www.ncbi.nlm.nih.gov/pubmed/12537605).

• Biochemistry (Moscow) 70(2) (2005), "Mitochondrial Metabolism of Reactive Oxygen Species", A Yu Andreyev (http://www.ncbi.nlm.nih.gov/pubmed/15807660).

• Am J. Physiol Lung Cell Mol Physiol, v279, pL1005-L1028 (2000), "Reactive Oxygen Species in cell signaling", Victor J. Thannickal and Barry L. Fanburg (http://www.ncbi.nlm.nih.gov/pubmed/11076791).

• Exp. Physiol., v90(4), p457-462 (May 2005), "New aspects of artery resistance and structure: Oxidative Stress and Vascular Remodelling", Ana Fortuno (http://www.ncbi.nlm.nih.gov/pubmed/15890797).

• Am J Physiol v275 pC1-C24 (1998), "Interaction of reactive oxygen species with ion transport mechanisms (an invited review)", Joseph I. Kourie (http://www.ncbi.nlm.nih.gov/pubmed/9688830).

• Arteriosclr Throm. Vasc. Biol., v20, p2175-2183 (2000), "Modulation of Protein Kinase Activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology", Kathy K. Griendling, et al. (http://www.ncbi.nlm.nih.gov/pubmed/11031201).

• J of Medical Microbio, v52, p643-651 (2003), "Reassessment of the microbicidal activity of reactive oxygen species and hypochlorous acid with reference to the phagocytic vacuole of the neutrophil granulocyte", Emer P. Reeves (http://www.ncbi.nlm.nih.gov/pubmed/12867557).

• Molec. Bio. of the Cell, v18, p2002-2012 (Jun 2007), "Superoxide Flux in Endothelial Cells via the Chloride Channel-3 Mediates Intracellular Signaling", B.J. Hawkins, M. Madesh, C.J. Kirkpatrick, A.B. Fisher (http://www.ncbi.nlm.nih.gov/pubmed/17360969).

• The J. of Cell Biology (JCB), v155(6), p1003-15 (Dec 2001), "VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release", M. Madesh, G. Hajonczky (http://www.ncbi.nlm.nih.gov/pubmed/11739410).

• Genes and Development, v15, p2922-2933 (2001), "The expanding role of mitochondria in apoptosis", X. Wang (http://www.ncbi.nlm.nih.gov/pubmed/11711427).